To improve therapy with several important drugs controlled release dosage forms have been extensively used. However, many times development process creates difficulties such as inability to localize and restrain dosage form within desire region of GIT and variable nature of gastric emptying process. This variability leads to unpredictable results, bioavailibity and varying plasma levels. The purpose of this review to compile information with special focus on sustained release gastro retentive dosage form that are recently leading methodology for control release of drug. There are various approaches uses for gastric retention of dosage form i.e. high density (sinking), floating, bio- or Mucoadhesive, expandable, unfoldable, super porous hydro gel and magnetic systems. Floating dosage form are emerging as promising dosage form. Floating dosage form can be prepared as tablet, capsule by adding suitable ingredient as well as gas generating agent. In this review various approaches used in gastro retentive drug delivery system along with recent development are discussed.
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